Is there any way to map keyboard function keys to the RDP host using SparkView? For example, F2 to rename a file, or Windows + E to launch explorer.

If keys are not reserved by the browser or OS, then they can be sent directly to the server, otherwise, you can:

Use the alternative (Admin Manual Appendix A):
Create a on-screen button or menu to send special keys, like Ctrl+Alt+Del, you can call rdp.writeKeyComb(‘Ctrl+Alt+Del’) to do that.